| http://purl.uniprot.org/citations/15166501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15166501 | http://www.w3.org/2000/01/rdf-schema#comment | "Human angiogenin is a 14-kDa secreted protein with angiogenic and ribonucleolytic activities. Angiogenin is associated with tumour development but is also present in normal biological fluids and tissues. To further address the physiological role of angiogenin, we studied its expression in situ and in vitro, using the human term placenta as a model of physiological angiogenesis. Angiogenin was immunodetected by light and transmission electron microscopy, and its cellular distribution was established by double immunolabelling with cell markers including von Willebrand factor, platelet/endothelial cell adhesion molecule-1 (PECAM-1), CD34, Tie-2, vascular endothelial cadherin (VE-cadherin), vascular endothelial growth factor receptor-2 (VEGF-R2), erythropoeitin receptor (Epo-R), alpha-smooth muscle actin, CD45, cytokeratin 7, and Ki-67. Angiogenin immunoreactivity was detected in villous and extravillous trophoblasts, the trophoblast basement membrane, the endothelial basal lamina, foetal blood vessels, foetal and maternal red blood cells, and amnionic cells. Its expression was confirmed by in situ hybridisation with a digoxygenin-labelled cDNA probe and reverse transcriptase-polymerase chain reaction amplification. Villous cytotrophoblasts, isolated and differentiated in vitro into a functional syncytiotrophoblast, expressed and secreted angiogenin. Given its known biological activities in vitro and its observed pattern of expression, these data suggest that, in human placenta, angiogenin has a role not only in angiogenesis but also in vascular and tissue homeostasis, maternal immune tolerance of the foetus, and host defences."xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.org/dc/terms/identifier | "doi:10.1023/b:agen.0000029412.95244.81"xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/author | "Frendo J.L."xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/author | "Bassaglia Y."xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/author | "Badet J."xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/author | "Hatzi E."xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/author | "Evain Brion D."xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/author | "Pavlov N."xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/name | "Angiogenesis"xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/pages | "317-330"xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/title | "Angiogenin distribution in human term placenta, and expression by cultured trophoblastic cells."xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/15166501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15166501 |
| http://purl.uniprot.org/citations/15166501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15166501 |
| http://purl.uniprot.org/uniprot/P03950#attribution-AC96B95727FC67D627FFE9130F6F325A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15166501 |
| http://purl.uniprot.org/uniprot/P03950#attribution-DFD91D2F35189FAF630B25FA93B2E910 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15166501 |
| http://purl.uniprot.org/uniprot/#_P03950-mappedCitation-15166501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166501 |
| http://purl.uniprot.org/uniprot/#_W0UV28-mappedCitation-15166501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166501 |
| http://purl.uniprot.org/uniprot/P03950 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15166501 |
| http://purl.uniprot.org/uniprot/W0UV28 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15166501 |