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http://purl.uniprot.org/citations/15166527http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15166527http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate possible correlates of HIV resistance in participants from the Amsterdam Cohort of Homosexual men who have remained HIV seronegative despite high-risk sexual behaviour.

Design/methods

We studied in vitro HIV-1 susceptibility and adaptive and innate immunity in 29 high-risk seronegative (HRSN) and 15 HIV-negative pre-seroconversion (pre-SC) homosexual men from the same Amsterdam Cohort Study (ACS) who seroconverted to HIV-1 positive during active follow-up. Host genetics were compared between HRSN and HIV-positive ACS participants.

Results

We found lower in vitro susceptibility for a CCR5-using (R5) HIV-1 variant, higher RANTES production levels, but no difference in coreceptor expression in HRSN as compared with pre-SC controls. Reduced R5 in vitro susceptibility of two HRSN tested was restored to normal levels by addition of antibodies against beta-chemokines. A higher proportion of HRSN carried the SDF-1 3'A variant and HLA-A*11, A*31 and Cw*15 alleles. ELIspot analysis with HIV-1 peptide stimulation revealed low frequencies of HIV-1-specific CD8 interferon-gamma producing cytotoxic T cells in both HRSN and pre-SC controls.

Conclusions

Low in vitro R5 susceptibility of cells from the HRSN men was due to beta-chemokine mediated inhibition of virus replication. The presence of HIV-1 specific cytotoxic T cells in both HRSN and pre-SC participants may signify exposure to the virus rather than protection from infection. Host genetic characteristics and other factors affecting innate immunity may contribute to differential resistance to HIV-1 infection among exposed seronegative individuals."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.org/dc/terms/identifier"doi:10.1097/00002030-200405210-00005"xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/author"Dekker J."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/author"Schuitemaker H."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/author"Prins M."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/author"Kaslow R.A."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/author"Koning F.A."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/author"van Baarle D."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/author"Dukers N."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/author"Jansen C.A."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/name"AIDS"xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/pages"1117-1126"xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/title"Correlates of resistance to HIV-1 infection in homosexual men with high-risk sexual behaviour."xsd:string
http://purl.uniprot.org/citations/15166527http://purl.uniprot.org/core/volume"18"xsd:string
http://purl.uniprot.org/citations/15166527http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15166527
http://purl.uniprot.org/citations/15166527http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15166527
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http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-15166527http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15166527
http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-15166527http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15166527
http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-15166527http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15166527
http://purl.uniprot.org/uniprot/#_A0A0G2R0N5-mappedCitation-15166527http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15166527
http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-15166527http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15166527
http://purl.uniprot.org/uniprot/#_A0A076L0P9-mappedCitation-15166527http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15166527
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