| http://purl.uniprot.org/citations/15175329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15175329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15175329 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphocyte homing is initiated by the binding of L-selectin on lymphocytes to its ligands on high endothelial venules (HEV). Sialyl 6-sulfo Lewis X is a major capping group of L-selectin ligands. N-Acetylglucosamine (GlcNAc) 6-sulfation is essential for the ligand activity, and is catalyzed by GlcNAc 6-O-sulfotransferases (GlcNAc6STs) of which GlcNAc6ST-1 and GlcNAc6ST-2 are expressed in HEV. Here, we report that mice deficient in GlcNAc6ST-1 were impaired in the elaboration of sialyl 6-sulfo Lewis X in HEV and that an epitope of L-selectin ligands recognized by the MECA-79 anti-body was greatly reduced or abolished in the abluminal aspect of HEV. Lymphocyte homing to peripheral lymph nodes, mesenteric lymph nodes, and Peyer's patches was significantly reduced in GlcNAc6ST-1 null mice. These results demonstrate that GlcNAc6ST-1 is involved in lymphocyte homing in vivo, and indicate that GlcNAc6ST-1 and -2 play complementary roles. The importance of GlcNAc6ST-1 is particularly high-lighted by its involvement in lymphocyte homing to Peyer's patches where GlcNAc6ST-2 expression is undetectable."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m404456200"xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m404456200"xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Takeda N."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Takeda N."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Muramatsu T."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Muramatsu T."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Izawa M."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Izawa M."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Kadomatsu K."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Kadomatsu K."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Singer M.S."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Singer M.S."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Rosen S.D."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Rosen S.D."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Uchimura K."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Uchimura K."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "El-Fasakhany F.M."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "El-Fasakhany F.M."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Kannagi R."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/author | "Kannagi R."xsd:string |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15175329 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |