| http://purl.uniprot.org/citations/15175423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15175423 | http://www.w3.org/2000/01/rdf-schema#comment | "One of the characteristics of drug dependence is that a drug has to be administered repeatedly before withdrawal effects can be observed. We have previously shown that withdrawal after 14 days of cocaine treatment produces a supersensitivity of hypothalamic 5-hydroxytryptamine (serotonin) 2A (5-HT(2A)) receptors, which is accompanied by increases in the levels of Galpha(q) and Galpha(11) proteins. Unfortunately, the exact duration of cocaine treatment necessary to induce alterations in G protein levels during cocaine withdrawal is unknown. The present study investigated the minimum cocaine treatment period required to produce changes in protein levels of membrane- and cytosol-associated Galpha(q) and Galpha(11) proteins in the hypothalamic paraventricular nucleus, amygdala, and frontal cortex. Rats were injected with cocaine (15 mg/kg i.p., b.i.d.) for 0, 1, 3, 5, and 7 days and tested after 2 days of withdrawal. The levels of Galpha(q) and Galpha(11) proteins were increased in the paraventricular nucleus and the amygdala but not in the frontal cortex. Although 1 and 3 days of cocaine treatment were sufficient to maximally elevate the protein levels of Galpha(11) and Galpha(q) proteins in the amygdala, 5 days of treatment were required to maximally increase the levels of Galpha(11) and Galpha(q) proteins in the paraventricular nucleus. The data suggest that the amygdala shows a faster neuroadaptation to the effects of cocaine than the hypothalamic paraventricular nucleus. These findings provide insight into the relative importance of individual components of 5-HT(2A) receptor signal transduction system in regulating the overall sensitivity of this signaling in cocaine-treated rats."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.org/dc/terms/identifier | "doi:10.1124/jpet.104.069807"xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/author | "Garcia F."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/author | "Battaglia G."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/author | "Muma N.A."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/author | "Van de Kar L.D."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/author | "Carrasco G.A."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/author | "D'Souza D.N."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/author | "Damjanoska K.J."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/name | "J Pharmacol Exp Ther"xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/pages | "349-355"xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/title | "Short-term cocaine treatment causes neuroadaptive changes in Galphaq and Galpha11 proteins in rats undergoing withdrawal."xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://purl.uniprot.org/core/volume | "311"xsd:string |
| http://purl.uniprot.org/citations/15175423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15175423 |
| http://purl.uniprot.org/citations/15175423 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15175423 |
| http://purl.uniprot.org/uniprot/#_D4AE68-mappedCitation-15175423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15175423 |
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| http://purl.uniprot.org/uniprot/#_A0A8I6G6A0-mappedCitation-15175423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15175423 |
| http://purl.uniprot.org/uniprot/#_G3V6Q6-mappedCitation-15175423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15175423 |
| http://purl.uniprot.org/uniprot/#_P82471-mappedCitation-15175423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15175423 |
| http://purl.uniprot.org/uniprot/#_P19627-mappedCitation-15175423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15175423 |
| http://purl.uniprot.org/uniprot/#_Q45QM4-mappedCitation-15175423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15175423 |