| http://purl.uniprot.org/citations/15180522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15180522 | http://www.w3.org/2000/01/rdf-schema#comment | "Several studies have examined the importance of ubiquitin-like posttranslational modifiers (which consist of an unexpectedly large family). Of these, NEDD8 (also called Rub1, related to ubiquitin 1) with a high homology to ubiquitin is covalently linked to all members of cullin (Cul)-family proteins through an enzymatic cascade analogous to ubiquitylation. Cul-family proteins are scaffold proteins for a wide series of ubiquitin-protein ligase complexes, such as SCFs (Skp1, Cul-1, Roc1, and F-box proteins), which regulate the degradation of broad range of cellular proteins. Unlike ubiquitin, which mostly acts as a degradation signal for the target proteins, NEDD8 acts as an activation signal for Cul-family proteins; i.e., Cul-based ubiquitin-protein ligases. Accordingly, the NEDD8 conjugation pathway regulating Cul-protein function is responsible for a diverse array of biologically important processes, such as the cell cycle progression, signalling cascades and developmental programs. Furthermore, recent studies have revealed that the COP9/Signalosome complex interacts physically and genetically with Cul-family proteins, and catalyzes deconjugation of NEDD8 ligated to Cul-family proteins. This review summarizes recent advances in biochemical and genetic studies on how the NEDD8-modifying system regulates Cul-family proteins and their physiology."xsd:string |
| http://purl.uniprot.org/citations/15180522 | http://purl.org/dc/terms/identifier | "doi:10.2174/1389203043379783"xsd:string |
| http://purl.uniprot.org/citations/15180522 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/15180522 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/15180522 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15180522 | http://purl.uniprot.org/core/name | "Curr Protein Pept Sci"xsd:string |
| http://purl.uniprot.org/citations/15180522 | http://purl.uniprot.org/core/pages | "177-184"xsd:string |
| http://purl.uniprot.org/citations/15180522 | http://purl.uniprot.org/core/title | "Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system."xsd:string |
| http://purl.uniprot.org/citations/15180522 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/15180522 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15180522 |
| http://purl.uniprot.org/citations/15180522 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15180522 |
| http://purl.uniprot.org/uniprot/#_P52286-mappedCitation-15180522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15180522 |
| http://purl.uniprot.org/uniprot/#_Q03919-mappedCitation-15180522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15180522 |
| http://purl.uniprot.org/uniprot/#_Q08273-mappedCitation-15180522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15180522 |
| http://purl.uniprot.org/uniprot/P52286 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15180522 |
| http://purl.uniprot.org/uniprot/Q03919 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15180522 |
| http://purl.uniprot.org/uniprot/Q08273 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15180522 |