| http://purl.uniprot.org/citations/15181200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15181200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15181200 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative stress, leading to the suggestion that DJ-1 is protective under these conditions. We addressed whether this represents a posttranslational modification at cysteine residues by systematically mutating cysteine residues in human DJ-1. WT or C53A DJ-1 was readily oxidized in cultured cells, generating a pI 5.8 isoform, but an artificial C106A mutant was not. We observed a cysteine-sulfinic acid at C106 in crystalline DJ-1 but no modification of C53 or C46. Oxidation of DJ-1 was promoted by the crystallization procedure. In addition, oxidation-induced mitochondrial relocalization of DJ-1 and protection against cell death were abrogated in C106A but not C53A or C46A. We suggest that DJ-1 protects against neuronal death, and that this is signaled by acidification of the key cysteine residue, C106."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0402959101"xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0402959101"xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Petsko G.A."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Petsko G.A."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Ringe D."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Ringe D."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Wilson M.A."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Wilson M.A."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Ahmad R."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Ahmad R."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Bandyopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Bandyopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Miller D.W."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Miller D.W."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Cookson M.R."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Cookson M.R."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Baptista M.J."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Baptista M.J."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Canet-Aviles R.M."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "Canet-Aviles R.M."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "McLendon C."xsd:string |
| http://purl.uniprot.org/citations/15181200 | http://purl.uniprot.org/core/author | "McLendon C."xsd:string |