| http://purl.uniprot.org/citations/15183529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15183529 | http://www.w3.org/2000/01/rdf-schema#comment | "The enhancement of cell proliferation and promotion of cell survival via the inhibition of apoptosis is thought to be the key to the initiation and progression of cancers. The phosphatidylinositol-3 kinase (PI3K)/Akt is an important survival signal pathway that has been shown to be crucial in the regulation of balance between pro-apoptotic and survival (anti-apoptotic) signal. In this study, the expression of phosphorylated Akt at Thr308 and Ser473, BCL-2-antagonist of cell death (BAD) at Ser136 and glycogen synthase kinase-3beta (GSK-3beta) at Ser9 in 47 paraffin-embedded human colorectal carcinoma (CRC) tissues were determined by immunohistochemical staining in order to dissect the alterations in the signal transduction pathways in CRC. Our results showed that there was a significant increase in the expression of these biomolecules in CRC tissues compared to the apparently normal adjacent tissues. The frequency of increased expression in tumor colonic mucosa were as follows: p-Akt1/2/3 (Thr308) = 16/47 (34%); p-Akt1 (Ser473) = 21/47 (44.7%); phospho-BAD (p-BAD) Ser136 = 27/47 (57.4%) and phospho-GSK-3beta (p-GSK-3beta) = 21/47 (44.7%). Analysis of the total p-Akt1 (Ser473), p-Akt1/2/3 (Thr308), p-GSK-3beta (Ser9) and p-BAD (Ser136) score found that there was a statistically significant relationship with each other. A statistically significant positive linear relationship was found between total p-Akt (Ser473) score and total p-GSK-3beta (Ser9) score as well as with total p-BAD (Ser136) score. On the other hand, total p-Akt1/2/3 (Thr308) scores had a statistically significant positive linear relationship with p-GSK-3beta (Ser9) only. The Akt targets, p-GSK-3beta (Ser9) and p-BAD (Ser136) were positively correlated to each other. There was no significant correlation between clinico-pathological data with total p-Akt1 (Ser473), p-Akt1/2/3 (Thr308), p-GSK-3beta (Ser9) and p-BAD (Ser136) score except for age. The total scores of p-GSK-3beta were found to be higher in patients in the age group of greater than 60. This is the first report of p-Akt1/2/3 (Thr308) and p-BAD (Ser136) expression in primary colorectal tumor tissue. Our data further supports the role of PI3K/Akt signaling pathways in the pathogenesis of CRC and contributes to the identification of target molecules in the signal transduction pathway for cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2004.01.017"xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/author | "Seow H.F."xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/author | "Ithnin H."xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/author | "Gul Y.A."xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/author | "Khor T.O."xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/pages | "139-150"xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/title | "Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma."xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://purl.uniprot.org/core/volume | "210"xsd:string |
| http://purl.uniprot.org/citations/15183529 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15183529 |
| http://purl.uniprot.org/citations/15183529 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15183529 |
| http://purl.uniprot.org/uniprot/#_P31749-mappedCitation-15183529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15183529 |
| http://purl.uniprot.org/uniprot/#_P31751-mappedCitation-15183529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15183529 |
| http://purl.uniprot.org/uniprot/#_Q92934-mappedCitation-15183529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15183529 |
| http://purl.uniprot.org/uniprot/#_Q9Y243-mappedCitation-15183529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15183529 |
| http://purl.uniprot.org/uniprot/P31749 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15183529 |
| http://purl.uniprot.org/uniprot/Q9Y243 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15183529 |
| http://purl.uniprot.org/uniprot/Q92934 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15183529 |
| http://purl.uniprot.org/uniprot/P31751 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15183529 |