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http://purl.uniprot.org/citations/15184603http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15184603http://www.w3.org/2000/01/rdf-schema#comment"

Background

The amyloid precursor protein (APP) locus on chromosome 21 influences the development of Alzheimer disease.

Method

The authors investigated the relationship between a tetranucleotide repeat on intron 7 of the APP gene and the age at onset of dementia in Down syndrome (DS).

Results

There was a 13-year difference in the age at onset of dementia in DS associated with the number of tetranucleotide repeat alleles in APP.

Conclusion

APP is an important locus predicting the age at onset of dementia in people with Down syndrome."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.org/dc/terms/identifier"doi:10.1212/01.wnl.0000129275.13169.be"xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/author"Tan A.L."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/author"Morris C.M."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/author"Gibson A.M."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/author"Moore B.P."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/author"Ballard C.G."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/author"Kay D.W."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/author"Margallo-Lana M."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/author"Tyrer S.P."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/name"Neurology"xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/pages"1996-1998"xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/title"Influence of the amyloid precursor protein locus on dementia in Down syndrome."xsd:string
http://purl.uniprot.org/citations/15184603http://purl.uniprot.org/core/volume"62"xsd:string
http://purl.uniprot.org/citations/15184603http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15184603
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http://purl.uniprot.org/uniprot/#_B4DQM1-mappedCitation-15184603http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15184603
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