| http://purl.uniprot.org/citations/15184869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15184869 | http://www.w3.org/2000/01/rdf-schema#comment | "AGS1/RASD1 is a Ras-related protein identified as a dexamethasone-inducible cDNA and as a signal regulator in various functional and protein-interaction screens. As an initial approach to define the role of AGS1/RASD1 as a Ras-family member, we determined its influence on cell growth/survival. In clonogenic assays with NIH-3T3 murine fibroblast cells, the MCF-7 human breast cancer cell line and the human lung adenocarcinoma cell line A549, AGS1/RASD1 markedly diminished the number of G418-resistant colonies, whereas the Ras subgroup member K-Ras was without effect. A549 cell infection with adenovirus engineered to express AGS1/RASD1 (Ad.AGS1) inhibited log phase growth in vitro and increased the percentage of cells undergoing apoptosis. The anti-growth action was also observed in vivo as the expression of AGS1/RASD1 inhibited the subcutaneous tumor growth of A549 cells in athymic nude mice. These data indicate that AGS1/RASD1, a member of the Ras superfamily of small G-proteins that often promotes cell growth and tumor expansion, plays an active role in preventing aberrant cell growth."xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207774"xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/author | "Lanier S.M."xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/author | "Brown K.D."xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/author | "Vaidyanathan G."xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/author | "Cismowski M.J."xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/author | "Vincent T.S."xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/pages | "5858-5863"xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/title | "The Ras-related protein AGS1/RASD1 suppresses cell growth."xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15184869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15184869 |
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| http://purl.uniprot.org/uniprot/#_Q9Y272-mappedCitation-15184869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15184869 |
| http://purl.uniprot.org/uniprot/Q9HC43 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15184869 |
| http://purl.uniprot.org/uniprot/Q9Y272 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15184869 |