| http://purl.uniprot.org/citations/15184895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15184895 | http://www.w3.org/2000/01/rdf-schema#comment | "The factors directing marginal zone B cells to the splenic marginal zone are not well understood. Here we report that FTY720, a drug that targets sphingosine 1-phosphate (S1P) receptors, induced marginal zone B cell migration into follicles. Marginal zone B cells expressed S1P receptors 1 and 3 (S1P(1) and S1P(3), respectively). Using gene-targeted mice, we show that S1P(1) but not S1P(3) was required for localization in the marginal zone. In mice lacking the chemokine CXCL13, S1P(1)-deficient marginal zone B cells reacquired a marginal zone distribution. Exposure to lipopolysaccharide or antigen caused marginal zone B cells to downregulate S1P(1) and S1P(3) and to migrate into the splenic white pulp. These data suggest that marginal zone B cell localization to the marginal zone depends on responsiveness to the blood lysophospholipid S1P, with S1P(1) signaling overcoming the recruiting activity of CXCL13."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1083"xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/author | "Lu T."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/author | "Proia R.L."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/author | "Low C."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/author | "Matloubian M."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/author | "Cinamon G."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/author | "Lesneski M.J."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/pages | "713-720"xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/title | "Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone."xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/15184895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15184895 |
| http://purl.uniprot.org/citations/15184895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15184895 |
| http://purl.uniprot.org/uniprot/#_O08530-mappedCitation-15184895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15184895 |
| http://purl.uniprot.org/uniprot/#_Q3U1E8-mappedCitation-15184895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15184895 |
| http://purl.uniprot.org/uniprot/#_K7XUH1-mappedCitation-15184895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15184895 |
| http://purl.uniprot.org/uniprot/#_O55038-mappedCitation-15184895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15184895 |
| http://purl.uniprot.org/uniprot/#_Q3UUK3-mappedCitation-15184895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15184895 |
| http://purl.uniprot.org/uniprot/#_Q99NR5-mappedCitation-15184895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15184895 |
| http://purl.uniprot.org/uniprot/#_Q8C4A3-mappedCitation-15184895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15184895 |