| http://purl.uniprot.org/citations/15186961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15186961 | http://www.w3.org/2000/01/rdf-schema#comment | "The variability of the Class B Type I Scavenger Receptor (SR-BI) gene in human populations and the relation of its variants to blood lipids was investigated in a random sample of 1756 untreated adult residents of Geneva, Switzerland, during 1999-2000. A three-step study approach yielded the following results: (1) resequencing the gene's exons and flanking regions in 95 subjects identified four common single nucleotide polymorphisms (SNPs with rare allele frequency >3%); (2) association study of the four common SNPs in subjects with extreme HDL-cholesterol (HDL-C) and LDL-C phenotypes (186 "atherogenic cases" and 185 "non-atherogenic controls") showed that the synonymous exon 8 C-T (allelic frequency 48%) polymorphism, A350A, was associated with atheroprotection in men (odds ratios (OR) = 0.36, 95% confidence intervals (CI) = 0.15-0.90, P < 0.03), but not in women (2.09, 0.79-5.49, P = 0.14); and (3) population clinical effects of A350A genotypes assessed in all 1756 subjects, showed that the case-control study findings reflected a protective HDL-C effect in men (CC: 1.17 mmol/L, CT: 1.22 mmol/L, and TT: 1.24 mmol/L, trend P = 0.0062) and a deleterious LDL-C effect in women (CC: 3.58 mmol/L, CT: 3.72 mmol/L, and TT: 3.79 mmol/L, trend P = 0.014). The allelic frequencies of the common SR-BI variants appear to be very similar in European and North American populations. The HDL-C effect increased with age. SR-BI A350A appears to have gender-specific and age-related effects on cholesterol transport lipoproteins."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.atherosclerosis.2004.03.014"xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Cayanis E."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "James R."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Alvin G.B."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Costanza M.C."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Das K."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Flaherty M.S."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Gilliam T.C."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Morabia A."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Ross B.M."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Yang A.S."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/author | "Evagrafov O."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/name | "Atherosclerosis"xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/pages | "159-168"xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/title | "Population-based study of SR-BI genetic variation and lipid profile."xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/15186961 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15186961 |
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