| http://purl.uniprot.org/citations/15187131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15187131 | http://www.w3.org/2000/01/rdf-schema#comment | "CD5 is a surface receptor constitutively expressed on thymocytes and mature T and B-1a cells. CD5 expression is tightly regulated during T and B cell development and activation processes. In this study we shown that the constitutive expression of CD5 on human T cells correlates with the presence of a DNase I-hypersensitive (DH) site at the 5'-flanking region of CD5. Human CD5 is a TATA-less gene for which 5'-RACE analysis shows multiple transcriptional start sites, the most frequent of which locates within an initiator sequence. Luciferase reporter assays indicate that a 282-bp region upstream of the initiation ATG displays full promoter activity in human T cells. Two conserved Ets-binding sites (at positions -239 and -185) were identified as functionally relevant to CD5 expression by site-directed mutagenesis, EMSAs, and cotransfection experiments. A possible contribution of Sp1 (-115 and -95), c-Myb (-177), and AP-1-like (-151) motifs was also detected. Further DH site analyses revealed an inducible DH site 10 kb upstream of the human CD5 gene in both T and B CD5(+) cells. Interestingly, a 140-bp sequence showing high homology with a murine inducible enhancer is found within that site. The data presented indicate that the 5'-flanking region of human CD5 is transcriptionally active in T cells, and that Ets transcription factors in conjunction with other regulatory elements are responsible for constitutive and tissue-specific CD5 expression."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.12.7519"xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/author | "Lopez-Cabrera M."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/author | "Santana M."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/author | "Lozano F."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/author | "Vives J."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/author | "Calvo J."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/author | "Arman M."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/author | "Cockerill P.N."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/author | "Trojanowska M.E."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/pages | "7519-7529"xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/title | "Transcriptional regulation of human CD5: important role of Ets transcription factors in CD5 expression in T cells."xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://purl.uniprot.org/core/volume | "172"xsd:string |
| http://purl.uniprot.org/citations/15187131 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15187131 |
| http://purl.uniprot.org/citations/15187131 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15187131 |
| http://purl.uniprot.org/uniprot/#_A0A384ME09-mappedCitation-15187131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15187131 |
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| http://purl.uniprot.org/uniprot/#_H6D9U9-mappedCitation-15187131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15187131 |
| http://purl.uniprot.org/uniprot/#_H6D9X2-mappedCitation-15187131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15187131 |
| http://purl.uniprot.org/uniprot/#_H6D9Y3-mappedCitation-15187131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15187131 |
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| http://purl.uniprot.org/uniprot/#_H6DA16-mappedCitation-15187131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15187131 |