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| http://purl.uniprot.org/citations/15189735 | http://www.w3.org/2000/01/rdf-schema#comment | "In the steady state, interaction between T cells and antigen-presenting dendritic cells (DCs) leads to T cell tolerance. To examine the role of DC regulated peripheral tolerance in a model autoimmune disease, we delivered an encephalitogenic oligodendrocyte glycoprotein (MOG) peptide to DCs in vivo. We found that targeting MOG peptide to DCs resulted in a novel form of peripheral T cell tolerance that was sufficiently profound to prevent autoimmune experimental acute encephalomyelitis (EAE). The tolerized T cells were severely impaired in specific secondary responses to antigen in vivo but they were not intrinsically anergic since they remained highly responsive to T cell receptor (TCR) stimulation in vitro. The mechanism that mediates this dynamic antigen-specific T cell unresponsiveness differs from previously described forms of tolerance in that it requires that DCs induce CD5 expression on activated T cells."xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2004.05.002"xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/author | "Nussenzweig M.C."xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/author | "Bettelli E."xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/author | "Masilamani R.F."xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/author | "Hawiger D."xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/pages | "695-705"xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/title | "Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo."xsd:string |
| http://purl.uniprot.org/citations/15189735 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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