| http://purl.uniprot.org/citations/15191952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15191952 | http://www.w3.org/2000/01/rdf-schema#comment | "Outcome of unrelated donor marrow transplantation is influenced by donor-recipient matching for HLA. Prior studies assessing the effects of mismatches at specific HLA loci have yielded conflicting results. The importance of high-resolution matching for all HLA loci has also not been established. We therefore examined the effects of HLA matching (low or high resolution or both) on engraftment, graft-versus-host disease (GVHD), and mortality in 1874 donor-recipient pairs retrospectively typed at high resolution for HLA-A, -B, -C, -DRB1, -DQ, and -DP. Mismatches at HLA-A, -B, -C, and -DRB1 each had similar adverse effects on mortality. Only HLA-A mismatches demonstrated significant adverse effects on GVHD. These adverse effects on outcome were more evident in transplants with low-resolution versus only high-resolution mismatches. Mismatches for HLA-DQ or -DP did not significantly affect outcome. When high-resolution mismatches at HLA-A, -B, -C, and -DRB1 were considered together, adverse effects on survival and GVHD were observed. We therefore conclude that matching for HLA-C should be incorporated into algorithms for unrelated donor selection. High-resolution mismatches at HLA-A, -B, -C, and -DRB1 adversely affect outcome, but less so than low-resolution mismatches. When clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2004-03-0803"xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Horowitz M."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Williams T."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Baxter-Lowe L.A."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Flomenberg N."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Begovich A."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Fernandez-Vina M."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Noreen H."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Setterholm M."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Trachtenberg E."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Hildebrand W."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Filipovich A."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Hurley C."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Petersdorf E."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Anasetti C."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Confer D."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Yunis E."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Schmeckpeper B."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Kollman C."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/author | "Weisdorf D."xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15191952 | http://purl.uniprot.org/core/pages | "1923-1930"xsd:string |