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http://purl.uniprot.org/citations/15192840http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15192840http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the association between the alleles of human leukocyte antigens (HLA)-DRB1 and essential hypertension (EH) in the Hans living in Yunnan of China.

Methods

The alleles of HLA-DRB1 were typed by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in samples from 83 patients with essential hypertension and 91 healthy controls. All of the subjects, their grandparents and grand-grandparents are Hans living in Yunnan of China.

Results

The frequency of DRB1*1501/2 in the EH patients (0.219) was significantly higher than that in the controls(0.060), chi quare=18.331, P<0.01. Relative risk (RR) was 4.46, and etiologic factor (EF) was 0.34. The frequency of DRB1*0901 significantly decreased in the group of patients with EH in comparison to the controls (0.081 versus 0.192) chi-square=8.704 P<0.05. RR was 0.41 and prevention factor(PF) was 0.19.

Conclusion

HLA-DRB1*1501/2 is associated with the susceptibility to essential hypertension in the Yunnan Hans of China. DRB1*0901 may protect one from the disease."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/author"Chen J."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/author"Wang W."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/author"Chen A.H."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/author"Cai X.M."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/author"Hu D.C."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/author"Shao J.C."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/author"Sun B.M."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/pages"286-287"xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/title"[Alleles of HLA class II DRB1 of patients with essential hypertension in Yunnan Hans]."xsd:string
http://purl.uniprot.org/citations/15192840http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/15192840http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15192840
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