| http://purl.uniprot.org/citations/15193260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15193260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15193260 | http://www.w3.org/2000/01/rdf-schema#comment | "We identified dynein light chain 1 (DLC1) as a physiologic substrate of p21-activated kinase 1 (Pak1). Pak1-DLC1 interaction plays an essential role in cell survival, which depends on Pak1's phosphorylation of DLC1 on Ser88. Pak1 associates with the complex of DLC1 and BimL, a proapoptotic BH3-only protein, and phosphorylates both proteins. Phosphorylation of BimL by Pak1 prevents it from interacting with and inactivation of Bcl-2, an antiapoptotic protein. Overexpression of DLC1 but not DLC1-Ser88Ala mutant promotes cancerous properties of breast cancer cells. DLC1 protein level is elevated in more than 90% of human breast tumors. The regulation of cell survival functions by Pak1-DLC1 interaction represents a novel mechanism by which a signaling kinase might regulate the cancerous phenotypes."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2004.05.022"xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2004.05.022"xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Nguyen D."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Nguyen D."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Vadlamudi R.K."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Vadlamudi R.K."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Balasenthil S."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Balasenthil S."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "den Hollander P."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "den Hollander P."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Sahin A.A."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Sahin A.A."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Bagheri-Yarmand R."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/author | "Bagheri-Yarmand R."xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/15193260 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |