| http://purl.uniprot.org/citations/15193417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15193417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15193417 | http://www.w3.org/2000/01/rdf-schema#comment | "Alpha-, beta-, gamma-, and delta-sarcoglycans (SGs) are transmembrane glycoprotein components of the dystrophin-associated protein (DAP) complex, which is critical for the stability of the striated muscle cell membrane. Epsilon-SG was found as a homologue of alpha-SG, but unlike other SG members, it is ubiquitously expressed in various tissues as well as in striated muscle. Moreover, mutations in the epsilon-SG gene cause myoclonus-dystonia, indicating the importance of epsilon-SG for the function in the central nervous system. To gain insight into the role of epsilon-SG, its expression and subcellular distribution in mouse tissues and especially in the mouse brain were investigated. Analysis by reverse transcription-polymerase chain reaction showed four splice variants of epsilon-SG transcripts in the mouse brain, two of which are major transcript forms. One is a conventional form including exon 8 (epsilon-SG1), and the other is a novel form excluding exon 8 but including a previously unknown exon, 11b (epsilon-SG2). Immunoblot analysis using various mouse tissues indicated a broad expression pattern for epsilon-SG1, but epsilon-SG2 was expressed exclusively in the brain. Therefore, both epsilon-SG isoforms coexist in various regions of the brain. Furthermore, these isoforms were found in neuronal cells using immunohistochemical analysis. Subcellular fractionation of brain homogenates, however, indicated that epsilon-SG1 and epsilon-SG2 are relatively enriched in post- and pre-synaptic membrane fractions, respectively. These results suggest that the two epsilon-SG isoforms might play different roles in synaptic functions of the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molbrainres.2004.01.012"xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molbrainres.2004.01.012"xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/author | "Endo T."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/author | "Endo T."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/author | "Takeda S."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/author | "Takeda S."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/author | "Imamura M."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/author | "Imamura M."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/author | "Nishiyama A."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/author | "Nishiyama A."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/name | "Brain Res. Mol. Brain Res."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/name | "Brain Res. Mol. Brain Res."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/pages | "1-12"xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/pages | "1-12"xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/title | "Identification and characterization of epsilon-sarcoglycans in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/title | "Identification and characterization of epsilon-sarcoglycans in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/15193417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15193417 |
| http://purl.uniprot.org/citations/15193417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15193417 |