| http://purl.uniprot.org/citations/15193430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15193430 | http://www.w3.org/2000/01/rdf-schema#comment | "A mutation in the mouse tub gene causes a phenotype characterized by maturity-onset obesity, blindness and deafness. The role of the intact tubby protein and the pathogenesis resulting in the phenotype of tub/tub mice remain largely unknown. In this study, we have investigated whether obese tub/tub mice exhibit altered expression levels for agouti-related protein (AGRP) or glutamic acid decarboxylase-65 (GAD65) in body weight-regulating neurons of the hypothalamic arcuate nucleus. In situ hybridization revealed that AGRP, but not GAD65 mRNA levels, were significantly lower in obese tub/tub mice as compared to tub/+ mice. The lower levels of AGRP mRNA in the arcuate nucleus of tub/tub mice were paralleled by lower fluorescence intensity and numbers of AGRP- and neuropeptide Y (NPY)-immunoreactive (ir) nerve fibers and terminals in the arcuate, ventromedial, dorsomedial hypothalamic nuclei and perifornical and lateral hypothalamic areas. No obvious differences in GAD65-ir nerve fibers and terminals could be detected. Measurements of daily food intake revealed that tub/tub mice displayed progressively higher food consumption as compared to lean tub/+ littermates over a 15-day observation period. When moved to an unfamiliar environment, e.g. a novel cage, daily food intake was initially lower in tub/tub mice than in tub/+ mice suggesting that tub/tub mice may be more sensitive to psychogenic stress. The results together show that tub/tub mice are hyperphagic and exhibit, within the hypothalamic arcuate nucleus, a depressed expression of neuropeptides involved in the regulation of feeding behavior."xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molbrainres.2004.03.012"xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/author | "Meister B."xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/author | "Madjid N."xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/author | "Ogren S.O."xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/author | "Backberg M."xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/pages | "129-139"xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/title | "Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice."xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/15193430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15193430 |
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