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http://purl.uniprot.org/citations/15199313http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15199313http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15199313http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15199313http://www.w3.org/2000/01/rdf-schema#comment"

Background

The three divergent HIV-1 groups M, N and O were very probably introduced into the human population by independent cross-species transmissions of SIVcpz from the chimpanzee subspecies Pan troglodytes troglodytes in central Africa.

Objective

To characterize HIV-1 group N strains and to elucidate the group's epidemiology and relationship to HIV-1 strains O and M, and SIVcpz.

Methods

DNA amplification, sequencing and phylogenetic analyses were performed to characterize viruses from three group N-infected individuals (YBF106, YBF115 and YBF116) together with YBF30 and YBF105 previously described.

Results

Full-length genome sequence was determined for virus YBF106; gag, pol and env sequences were obtained for YBF116; pol (integrase) and env (gp41) fragments were obtained for YBF115. The gag, pol, 5'-vif and nef sequences were phylogenetically more closely related to HIV-1 M while 3'-vif, vpr, tat, vpu and env clustered with SIVcpz from P. t. troglodytes. Sequence analysis revealed no mutations potentially responsible for drug resistance.

Conclusions

The finding that all group N viruses displayed the same recombinant structure and were monophyletic indicates that a single transfer event of SIVcpz to humans can account for the origin of this group. Despite the pathogenic outcome of the known group N infections, the extremely low prevalence of this divergent HIV-1 suggests that this group is not an emerging threat to human health at the present time. However, continuous monitoring of HIV-1 diversity will be important to survey the potential of unusual HIV infections, such as group N, to contribute to the HIV/AIDS pandemic."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.org/dc/terms/identifier"doi:10.1097/01.aids.0000125990.86904.28"xsd:string
http://purl.uniprot.org/citations/15199313http://purl.org/dc/terms/identifier"doi:10.1097/01.aids.0000125990.86904.28"xsd:string
http://purl.uniprot.org/citations/15199313http://purl.org/dc/terms/identifier"doi:10.1097/01.aids.0000125990.86904.28"xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Roques P."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Roques P."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Roques P."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Apetrei C."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Apetrei C."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Apetrei C."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Barre-Sinoussi F."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Barre-Sinoussi F."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Barre-Sinoussi F."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Muller-Trutwin M."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Muller-Trutwin M."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Muller-Trutwin M."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Nerrienet E."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Nerrienet E."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Nerrienet E."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Robertson D.L."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Robertson D.L."xsd:string
http://purl.uniprot.org/citations/15199313http://purl.uniprot.org/core/author"Robertson D.L."xsd:string
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