| http://purl.uniprot.org/citations/15200957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15200957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15200957 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptotic cell death and survival is controlled by pro- and antiapoptotic proteins. Because these proteins act on each other, cell fate is dictated by the relative activity of pro-versus antiapoptotic proteins. Here we report that BRUCE, a conserved 528 kDa peripheral membrane protein of the trans-Golgi network, protects cells against apoptosis and functions as an inhibitor of apoptosis (IAP). By using wild-type and mutant forms we show that BRUCE inhibits caspase activity and apoptosis depending on its BIR domain. Upon apoptosis induction, BRUCE is antagonized by three mechanisms: first, through binding to Smac; second, by the protease HtrA2; and third, by caspase-mediated cleavage. In addition to its IAP activity BRUCE has the distinctive property of functioning as a chimeric E2/E3 ubiquitin ligase with Smac being a substrate. Our work suggests that, owing to its two activities and its localization, BRUCE may function as a specialized regulator of cell death pathways."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.05.018"xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.05.018"xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/author | "Pohl C."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/author | "Pohl C."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/author | "Jentsch S."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/author | "Jentsch S."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/author | "Pyrowolakis G."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/author | "Pyrowolakis G."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/author | "Bartke T."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/author | "Bartke T."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/pages | "801-811"xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/pages | "801-811"xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/title | "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/title | "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/15200957 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15200957 |
| http://purl.uniprot.org/citations/15200957 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15200957 |