| http://purl.uniprot.org/citations/15201046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15201046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15201046 | http://www.w3.org/2000/01/rdf-schema#comment | "Mcm10 has recently been found to play a crucial role in multiple steps of the DNA replication initiation process in eukaryotes. Here, we have examined the role of Mcm10 in assembling initiation factors at a well-characterized yeast replication origin, ARS1. We find that the pre-replication complex (pre-RC) components Cdc6 and Mcm7 associate with ARS1 in the mcm10-1 mutant, suggesting that establishment of the pre-RC is not compromised in this mutant. Association of Cdc45 with ARS1 is reduced in the mcm10-1 mutant, suggesting that Mcm10 is involved in recruiting Cdc45 to the pre-RC. We find that overexpression of either Mcm10-1 or Cdc45 suppresses the growth defect of mcm10-1, and that a physical interaction between Cdc45 and Mcm10 is disrupted in the mcm10-1 mutant. Our results show that interaction between the Mcm10 and Cdc45 proteins facilitates the recruitment of Cdc45 onto the ARS1 origin."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2004.04.066"xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2004.04.066"xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/author | "Sawyer S.L."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/author | "Sawyer S.L."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/author | "Chai W."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/author | "Chai W."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/author | "Cheng I.H."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/author | "Cheng I.H."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/author | "Tye B.K."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/author | "Tye B.K."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/pages | "195-202"xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/pages | "195-202"xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/title | "Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/title | "Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/volume | "340"xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://purl.uniprot.org/core/volume | "340"xsd:string |
| http://purl.uniprot.org/citations/15201046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15201046 |
| http://purl.uniprot.org/citations/15201046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15201046 |