| http://purl.uniprot.org/citations/15201285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15201285 | http://www.w3.org/2000/01/rdf-schema#comment | "A mature form of nuclear-encoded mitochondrial serine protease HtrA2/Omi is pivotal in regulating apoptotic cell death; however, the underlying mechanism of the processing event of HtrA2/Omi and its relevant biological function remain to be clarified. Here, we describe that HtrA2/Omi is autocatalytically processed to the 36-kDa protein fragment, which is required for the cytochrome c-dependent caspase activation along with neutralizing XIAP-mediated inhibition of caspases through interaction with XIAP, eventually promoting apoptotic cell death. We have shown that the autocatalytic processing of HtrA2/Omi occurs via an intermolecular event, demonstrated by incubating an in vitro translated HtrA2/Omi (S306A) mutant with the enzymatically active glutathione S-transferase-HtrA2/Omi protein. Using N-terminal amino acid sequencing and mutational analysis, we identified that the autocatalytic cleavage site is the carboxyl side of alanine 133 of HtrA2/Omi, resulting in exposure of an inhibitor of apoptosis protein binding motif in its N terminus. Our study provides evidence that the autocatalytic processing of HtrA2/Omi is crucial for regulating HtrA2/Omi-mediated apoptotic cell death."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m401408200"xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Choi J.Y."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Kim K.J."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Kim I.K."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Park H.J."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Ahn S.G."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Rhim H."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Seong Y.M."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/author | "Seong G.H."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/pages | "37588-37596"xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/title | "Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP."xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15201285 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15201285 |
| http://purl.uniprot.org/citations/15201285 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15201285 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG44-mappedCitation-15201285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15201285 |
| http://purl.uniprot.org/uniprot/#_A0A384MDW9-mappedCitation-15201285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15201285 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3SIX7-mappedCitation-15201285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15201285 |
| http://purl.uniprot.org/uniprot/#_A8K7G2-mappedCitation-15201285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15201285 |
| http://purl.uniprot.org/uniprot/#_B2BKJ3-mappedCitation-15201285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15201285 |
| http://purl.uniprot.org/uniprot/#_O43464-mappedCitation-15201285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15201285 |