| http://purl.uniprot.org/citations/15208314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15208314 | http://www.w3.org/2000/01/rdf-schema#comment | "Yeast mutants defective in sphingolipid mannosylation accumulate inositol phosphorylceramide C (IPC-C), which renders cells Ca(2+)-sensitive. A screen for loss of function suppressors of the Ca(2+)-sensitive phenotype previously led to the identification of numerous genes involved in IPC-C synthesis. To better understand the molecular basis of the Ca(2+)-induced growth defect in IPC-C-overaccumulating cells, we searched for genes whose overexpression restored Ca(2+) tolerance in a mutant lacking the IPC mannosyltransferases Csg1p and Csh1p. Here we report the isolation of HOR7 as a multicopy suppressor of the Ca(2+)-sensitive phenotype of Deltacsg1Deltacsh1 cells. HOR7 belongs to a group of hyperosmolarity-responsive genes and encodes a small (59-residue) type I membrane protein that localizes at the plasma membrane. Hor7p is not required for high Ca(2+) or Na(+) tolerance. Instead, we find that Hor7p-overproducing cells display an increased resistance to high salt, sensitivity to low pH, and a reduced uptake of methylammonium, an indicator of the plasma membrane potential. These phenotypes are induced through a mechanism independent of the plasma membrane H(+)-ATPase, Pma1p. Our findings suggest that induction of Hor7p causes a depolarization of the plasma membrane that may counteract a Ca(2+)-induced influx of toxic cations in IPC-C-overaccumulating cells."xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m406197200"xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://purl.uniprot.org/core/author | "Holthuis J.C."xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://purl.uniprot.org/core/author | "Lisman Q."xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://purl.uniprot.org/core/author | "Urli-Stam D."xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15208314 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://purl.uniprot.org/core/pages | "36390-36396"xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://purl.uniprot.org/core/title | "HOR7, a multicopy suppressor of the Ca2+-induced growth defect in sphingolipid mannosyltransferase-deficient yeast."xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15208314 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15208314 |
| http://purl.uniprot.org/citations/15208314 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15208314 |
| http://purl.uniprot.org/uniprot/Q05827#attribution-171036187E4733ECF1E562A764B7076B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15208314 |
| http://purl.uniprot.org/uniprot/Q05827#attribution-D6C6DA503A6065486D50F25EAA3E5AF4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15208314 |
| http://purl.uniprot.org/uniprot/#_Q05827-mappedCitation-15208314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15208314 |
| http://purl.uniprot.org/uniprot/Q05827 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15208314 |