| http://purl.uniprot.org/citations/15210111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15210111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15210111 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin-dependent kinase (CDK) activity initiates the eukaryotic cell division cycle by turning on a suite of gene expression in late G1 phase. In metazoans, CDK-dependent phosphorylation of the retinoblastoma tumor suppressor protein (Rb) alleviates repression of E2F and thereby activates G1/S transcription. However, in yeast, an analogous G1 phase target of CDK activity has remained elusive. Here we show that the cell size regulator Whi5 inhibits G1/S transcription and that this inhibition is relieved by CDK-mediated phosphorylation. Deletion of WHI5 bypasses the requirement for upstream activators of the G1/S transcription factors SBF/MBF and thereby accelerates the G1/S transition. Whi5 is recruited to G1/S promoter elements via its interaction with SBF/MBF in vivo and in vitro. In late G1 phase, CDK-dependent phosphorylation dissociates Whi5 from SBF and drives Whi5 out of the nucleus. Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription. These findings harmonize G1/S control in eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.05.024"xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.05.024"xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Andrews B."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Andrews B."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Costanzo M."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Costanzo M."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Tyers M."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Tyers M."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Dewar D."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Dewar D."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Schub O."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Schub O."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Nishikawa J.L."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Nishikawa J.L."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Millman J.S."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Millman J.S."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Rupes I."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Rupes I."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Breitkreuz K."xsd:string |
| http://purl.uniprot.org/citations/15210111 | http://purl.uniprot.org/core/author | "Breitkreuz K."xsd:string |