| http://purl.uniprot.org/citations/15210730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15210730 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis after growth factor withdrawal or drug treatment is associated with mitochondrial cytochrome c release and activation of Apaf-1 and caspase-9. To determine whether loss of Apaf-1, caspase-2, and caspase-9 prevented death of factor-starved cells, allowing them to proliferate when growth factor was returned, we generated IL-3-dependent myeloid lines from gene-deleted mice. Long after growth factor removal, cells lacking Apaf-1, caspase-9 or both caspase-9 and caspase-2 appeared healthy, retained intact plasma membranes, and did not expose phosphatidylserine. However, release of cytochrome c still occurred, and they failed to form clones when IL-3 was restored. Cells lacking caspase-2 alone had no survival advantage. Therefore, Apaf-1, caspase-2, and caspase-9 are not required for programmed cell death of factor-dependent cells, but merely affect its rate. In contrast, transfection with Bcl-2 provided long-term, clonogenic protection, and could act independently of the apoptosome. Unlike expression of Bcl-2, loss of Apaf-1, caspase-2, or caspase-9 would therefore be unlikely to enhance the survival of cancer cells."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200312031"xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Kaufmann H."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Vaux D.L."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Hawkins C.J."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Silke J."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Ekert P.G."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Read S.H."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Marsden V.S."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/author | "Gerl R."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/pages | "835-842"xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/title | "Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die."xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://purl.uniprot.org/core/volume | "165"xsd:string |
| http://purl.uniprot.org/citations/15210730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15210730 |
| http://purl.uniprot.org/citations/15210730 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15210730 |
| http://purl.uniprot.org/uniprot/#_A2AS93-mappedCitation-15210730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15210730 |
| http://purl.uniprot.org/uniprot/#_G3XA09-mappedCitation-15210730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15210730 |
| http://purl.uniprot.org/uniprot/#_O88879-mappedCitation-15210730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15210730 |
| http://purl.uniprot.org/uniprot/#_Q4FJK5-mappedCitation-15210730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15210730 |
| http://purl.uniprot.org/uniprot/#_Q3TRE1-mappedCitation-15210730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15210730 |
| http://purl.uniprot.org/uniprot/#_Q5DU30-mappedCitation-15210730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15210730 |