| http://purl.uniprot.org/citations/15210732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15210732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15210732 | http://www.w3.org/2000/01/rdf-schema#comment | "Here, we describe a new muscle LIM domain protein, UNC-95, and identify it as a novel target for the RING finger protein RNF-5 in the Caenorhabditis elegans body wall muscle. unc-95(su33) animals have disorganized muscle actin and myosin-containing filaments as a result of a failure to assemble normal muscle adhesion structures. UNC-95 is active downstream of PAT-3/beta-integrin in the assembly pathways of the muscle dense body and M-line attachments, and upstream of DEB-1/vinculin in the dense body assembly pathway. The translational UNC-95::GFP fusion construct is expressed in dense bodies, M-lines, and muscle-muscle cell boundaries as well as in muscle cell bodies. UNC-95 is partially colocalized with RNF-5 in muscle dense bodies and its expression and localization are regulated by RNF-5. rnf-5(RNAi) or a RING domain deleted mutant, rnf-5(tm794), exhibit structural defects of the muscle attachment sites. Together, our data demonstrate that UNC-95 constitutes an essential component of muscle adhesion sites that is regulated by RNF-5."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200401133"xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200401133"xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Podbilewicz B."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Podbilewicz B."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Bhoumik A."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Bhoumik A."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Ronai Z."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Ronai Z."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Broday L."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Broday L."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Kolotuev I."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Kolotuev I."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Didier C."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/author | "Didier C."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/pages | "857-867"xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/pages | "857-867"xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/title | "The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/15210732 | http://purl.uniprot.org/core/title | "The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans."xsd:string |