| http://purl.uniprot.org/citations/15210819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15210819 | http://www.w3.org/2000/01/rdf-schema#comment | "Leukocyte cell-derived chemotaxin 2 (LECT2) was originally identified for its possible chemotactic activity against human neutrophils in vitro. It is a 16-kDa protein that is preferentially expressed in the liver. Its homologues have been widely identified in many vertebrates. Current evidence suggests that LECT2 may be a multifunctional protein like cytokines. However, the function of LECT2 in vivo remains unclear. To elucidate the role of this protein in vivo, we have generated LECT2-deficient (LECT2(-/-)) mice. We found that the proportion of NKT cells in the liver increased significantly in LECT2(-/-) mice, although those of conventional T cells, NK cells, and other cell types were comparable with those in wild-type mice. Consistent with increased hepatic NKT cell number, the production of IL-4 and IFN-gamma was augmented in LECT2(-/-) mice upon stimulation with alpha-galactosylceramide, which specifically activates Valpha14 NKT cells. In addition, NKT cell-mediated cytotoxic activity against syngeneic thymocytes increased in hepatic mononuclear cells obtained from LECT2(-/-) mice in vitro. Interestingly, the hepatic injury was exacerbated in LECT2(-/-) mice upon treatment with Con A, possibly because of the significantly higher expression of IL-4 and Fas ligand. These results suggest that LECT2 might regulate the homeostasis of NKT cells in the liver and might be involved in the pathogenesis of hepatitis."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.1.579"xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Okumura A."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Suzuki K."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Watanabe H."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Asano M."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Sudo K."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Abo T."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Yamagoe S."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Bezbradica J.S."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Joyce S."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Sakagami J."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Ishida-Okawara A."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/author | "Hatano-Yokoe Y."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/pages | "579-585"xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/title | "Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis."xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/15210819 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15210819 |
| http://purl.uniprot.org/citations/15210819 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15210819 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0R8-mappedCitation-15210819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15210819 |