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http://purl.uniprot.org/citations/15212671http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15212671http://www.w3.org/2000/01/rdf-schema#comment"

Problem

Tumor necrosis factor (TNF)-alpha is a major cytokine involved in inflammatory and immune function. The aim of this study was to investigate whether polymorphisms at positions -1031, -863 and -857 in the TNF gene promoter region (TNFA) and TNF receptor type 2 gene (TNFR2) are responsible in part for genetic susceptibility to endometriosis.

Methods of study

TNFA and TNFR2 polymorphisms were determined in 123 patients with endometriosis and 165 fertile healthy women by the polymerase chain reaction (PCR) - preferential homoduplex formation assay and PCR-restriction fragment length polymorphism, respectively.

Results

The frequency of the TNFA-U01 haplotype was increased significantly in patients with endometriosis compared with controls (P = 0.045, OR = 1.45). The TNFA-U01 haplotype was strongly associated with HLA-B*0702. No difference was found in TNFR2 polymorphism between patients and controls.

Conclusion

Our results indicated that TNFA promoter polymorphism was associated with susceptibility to endometriosis. However, this association was not independent of HLA-class I polymorphisms."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.org/dc/terms/identifier"doi:10.1111/j.1600-0897.2004.00168.x"xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Nakamura N."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Matsushita M."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Ohta M."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Yoshikawa T."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Teramoto M."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Saji H."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Kitaoka Y."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Obayashi H."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Hasegawa G."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Honjo H."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Maruya E."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Kitawaki J."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/author"Koshiba H."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/name"Am J Reprod Immunol"xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/pages"352-357"xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/title"Genetic contribution of tumor necrosis factor (TNF)-alpha gene promoter (-1031, -863 and -857) and TNF receptor 2 gene polymorphisms in endometriosis susceptibility."xsd:string
http://purl.uniprot.org/citations/15212671http://purl.uniprot.org/core/volume"51"xsd:string
http://purl.uniprot.org/citations/15212671http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15212671
http://purl.uniprot.org/citations/15212671http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15212671
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-15212671http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15212671
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-15212671http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15212671
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