| http://purl.uniprot.org/citations/15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15212826 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 (IL-1) gene polymorphisms are associated with an increased risk of Alzheimer's disease (AD) and it has been suggested that altered immune responses of the brain may play a role in the pathogenesis of the disease. Here we investigated whether IL-1beta polymorphisms affected neuro-pathological features and clinical status of AD patients with autopsy confirmed diagnosis of the disease. AD patients (n=133) were genotyped for the polymorphic regions in the apolipoprotein E epsilon (APOE epsilon) and interleukin-1beta (IL-1beta) genes. APOE epsilon4 carriers showed increased neuritic amyloid plaques (NP) and neurofibrillary tangles (NFT). The IL-1beta +3953 polymorphism influenced survival in AD patients and those with the TT genotype and without the APOE epsilon4 allele showed the shortest cumulative survival. Patients with the +3953 IL-1beta T and without the APOE epsilon4 alleles had reduced NP and NFT, a delayed ages at onset and death, but a decreased duration of the disease. On the other hand a different polymorphism of the IL-1beta gene at position -511 did not influence any AD features. Our findings suggest that IL-1beta gene by affecting brain immune responses may influence the age at onset of the disease, survival and AD progression."xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2003.11.002"xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/author | "Masliah E."xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/author | "Licastro F."xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/author | "Grimaldi L.M."xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/author | "Veglia F."xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/author | "Chiappelli M."xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/pages | "1017-1022"xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/title | "A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/15212826 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15212826 |
| http://purl.uniprot.org/citations/15212826 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15212826 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3B1-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3V0-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |
| http://purl.uniprot.org/uniprot/#_A0A510GAG5-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D5-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3J5-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |
| http://purl.uniprot.org/uniprot/#_A0A346DBY2-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |
| http://purl.uniprot.org/uniprot/#_D9ZB55-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |
| http://purl.uniprot.org/uniprot/#_A0AA51YZX7-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |
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| http://purl.uniprot.org/uniprot/#_J9ZVQ3-mappedCitation-15212826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15212826 |