| http://purl.uniprot.org/citations/15215582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15215582 | http://www.w3.org/2000/01/rdf-schema#comment | "Androgen receptor (hAR) regulates transcription of target genes in a ligand-dependent manner and recruits a number of co-activators for the ligand-induced transactivation via the N-terminal, activation function-1 (AF-1), and C-terminal, AF-2, transactivation domains. But the co-regulator functions on each of AR domains have not yet been fully understood. We have established a Drosophila transgenic system in which hAR and its deletion mutants are ectopically expressed in fly tissues together with an AR response element (ARE)-GFP reporter gene, and have confirmed that hAR was functional in ARE transactivation without affecting the expression of endogenous genes. We found that transcriptional activity of the hAR AF-1 domain was markedly reduced in Drosophila deficiency mutants of homologs for known mammalian co-activators of the AR ligand-dependent AF-2 domain. This suggests that hAR AF-1 recruits co-activators previously known only to interact with the AF-2 domain. Therefore, Drosophila with the hAR AF-1 transgene provides a relevant genetic system in which to uncover novel functions of vertebrate steroid hormone receptors and to screen for novel AF-1 co-regulators."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.org/dc/terms/identifier | "doi:10.1271/bbb.68.1209"xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Kato S."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Yamagata K."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Yamamoto A."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Suzuki E."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Sawatsubashi S."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Takeyama K."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Tabata T."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Maki A."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Kouzmenko A."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/author | "Shirode Y."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/name | "Biosci Biotechnol Biochem"xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/pages | "1209-1215"xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/title | "A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor."xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/15215582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15215582 |
| http://purl.uniprot.org/citations/15215582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15215582 |
| http://purl.uniprot.org/uniprot/#_A0A087WUX9-mappedCitation-15215582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15215582 |
| http://purl.uniprot.org/uniprot/#_E1JGY2-mappedCitation-15215582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15215582 |
| http://purl.uniprot.org/uniprot/#_D2KF13-mappedCitation-15215582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15215582 |