| http://purl.uniprot.org/citations/15215856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15215856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15215856 | http://www.w3.org/2000/01/rdf-schema#comment | "Elimination of misfolded proteins from the endoplasmic reticulum (ER) by retro-translocation is an important physiological adaptation to ER stress. This process requires recognition of a substrate in the ER lumen and its subsequent movement through the membrane by the cytosolic p97 ATPase. Here we identify a p97-interacting membrane protein complex in the mammalian ER that links these two events. The central component of the complex, Derlin-1, is a homologue of Der1, a yeast protein whose inactivation prevents the elimination of misfolded luminal ER proteins. Derlin-1 associates with different substrates as they move through the membrane, and inactivation of Derlin-1 in C. elegans causes ER stress. Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP, a novel membrane protein that recruits the p97 ATPase and its cofactor."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02656"xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02656"xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Shibata Y."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Shibata Y."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Rapoport T.A."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Rapoport T.A."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Yun C."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/author | "Yun C."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/pages | "841-847"xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/pages | "841-847"xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/title | "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/title | "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol."xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/volume | "429"xsd:string |
| http://purl.uniprot.org/citations/15215856 | http://purl.uniprot.org/core/volume | "429"xsd:string |