| http://purl.uniprot.org/citations/15218143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15218143 | http://www.w3.org/2000/01/rdf-schema#comment | "Arrestin regulates almost all G protein-coupled receptor (GPCR)-mediated signaling and trafficking. We report that the multidomain protein, spinophilin, antagonizes these multiple arrestin functions. Through blocking G protein receptor kinase 2 (GRK2) association with receptor-Gbetagamma complexes, spinophilin reduces arrestin-stabilized receptor phosphorylation, receptor endocytosis, and the acceleration of mitogen-activated protein kinase (MAPK) activity following endocytosis. Spinophilin knockout mice were more sensitive than wild-type mice to sedation elicited by stimulation of alpha2 adrenergic receptors, whereas arrestin 3 knockout mice were more resistant, indicating that the signal-promoting, rather than the signal-terminating, roles of arrestin are more important for certain response pathways. The reciprocal interactions of GPCRs with spinophilin and arrestin represent a regulatory mechanism for fine-tuning complex receptor-orchestrated cell signaling and responses."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1098274"xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/author | "Limbird L.E."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/author | "Allen P.B."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/author | "Brady A.E."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/pages | "1940-1944"xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/title | "Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors."xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://purl.uniprot.org/core/volume | "304"xsd:string |
| http://purl.uniprot.org/citations/15218143 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15218143 |
| http://purl.uniprot.org/citations/15218143 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15218143 |
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