| http://purl.uniprot.org/citations/15220135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15220135 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular cell adhesion molecule (VCAM)-1 supports specific eosinophil adhesion via alpha4beta1 integrin. We tested the hypothesis that adhesive contacts formed by eosinophils on VCAM-1 are different from focal adhesions formed by adherent fibroblasts. Eosinophils adherent on VCAM-1 formed punctate adhesions that fit the criteria for podosomes, highly dynamic structures found in adherent transformed fibroblasts, osteoclasts, and macrophages. The structures contained beta1 integrin subunit, phosphotyrosine-containing proteins, punctate filamentous actin, and gelsolin, a podosome marker. In contrast, nontransformed fibroblasts on VCAM-1 formed peripheral focal adhesions that were positive for alpha4, beta1, phosphotyrosine, vinculin, talin, and paxillin; negative for gelsolin; and associated with microfilaments. Phorbol myristate acetate or tumor necrosis factor-alpha and interleukin-5 stimulated podosome formation in adherent eosinophils. Because podosomes in tumor cells are associated with extracellular matrix degradation, we analyzed the VCAM-1 layer. VCAM-1 was lost under adherent eosinophils but not under adherent fibroblasts. This loss was inhibited by the metalloproteinase inhibitor ortho-phenanthroline and correlated with expression and podosome localization of a membrane-tethered metalloproteinase, a disintegrin and metalloproteinase domain 8. Podosome-mediated VCAM-1 clearance may be a mechanism to regulate eosinophil arrest and extravasation in allergic conditions such as asthma."xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2004-0099oc"xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/author | "Mosher D.F."xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/author | "Annis D.S."xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/author | "Barthel S.R."xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/author | "Johansson M.W."xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/author | "Duffy A.K."xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/author | "Lye M.H."xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/pages | "413-422"xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/title | "Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes."xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/15220135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15220135 |
| http://purl.uniprot.org/citations/15220135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15220135 |
| http://purl.uniprot.org/uniprot/P78325#attribution-D6854C9ADF8FF5CE043641A8F98BC821 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220135 |
| http://purl.uniprot.org/uniprot/P04141#attribution-D6854C9ADF8FF5CE043641A8F98BC821 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220135 |
| http://purl.uniprot.org/uniprot/P05113#attribution-D6854C9ADF8FF5CE043641A8F98BC821 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220135 |
| http://purl.uniprot.org/uniprot/P01375#attribution-D6854C9ADF8FF5CE043641A8F98BC821 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220135 |
| http://purl.uniprot.org/uniprot/P19320#attribution-D6854C9ADF8FF5CE043641A8F98BC821 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220135 |