| http://purl.uniprot.org/citations/15220933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15220933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15220933 | http://www.w3.org/2000/01/rdf-schema#comment | "Specialized oxygen-sensing cells in the nervous system generate rapid behavioural responses to oxygen. We show here that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5-12% oxygen, avoiding higher and lower oxygen levels. 3',5'-cyclic guanosine monophosphate (cGMP) is a common second messenger in sensory transduction and is implicated in oxygen sensation. Avoidance of high oxygen levels by C. elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35. The GCY-35 haem domain binds molecular oxygen, unlike the haem domains of classical nitric-oxide-regulated guanylate cyclases. GCY-35 and TAX-4 mediate oxygen sensation in four sensory neurons that control a naturally polymorphic social feeding behaviour in C. elegans. Social feeding and related behaviours occur only when oxygen exceeds C. elegans' preferred level, and require gcy-35 activity. Our results suggest that GCY-35 is regulated by molecular oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02714"xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02714"xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Gray J.M."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Gray J.M."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Marletta M.A."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Marletta M.A."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Chang J.S."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Chang J.S."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Bargmann C.I."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Bargmann C.I."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Ellis R.E."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Ellis R.E."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Chang A.J."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Chang A.J."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Karow D.S."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/author | "Karow D.S."xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/15220933 | http://purl.uniprot.org/core/name | "Nature"xsd:string |