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| http://purl.uniprot.org/citations/15224091 | http://www.w3.org/2000/01/rdf-schema#comment | "The proteasome is key in the cascade of proteolytic processing required for the generation of peptides presented at the cell surface to cytotoxic T lymphocytes by major histocompatibility complex class I molecules. Proteasome-dependent epitope processing is greatly improved through the interferon-gamma-induced formation of immunoproteasomes and the activator complex PA28. Tripeptidyl aminopeptidase II also has a strong effect on epitope generation. With its endoproteolytic and exoproteolytic activities, TPPII acts 'downstream' of the proteasome and relies on products released by the proteasome. The antigen-processing cascade involving different proteolytic systems raises anew the question of how antigenic peptides are generated. We therefore revisit the interferon-gamma-induced immune adaptation of the proteasome and attempt to redefine its function in connection with the emerging importance of TPPII."xsd:string |
| http://purl.uniprot.org/citations/15224091 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1090"xsd:string |
| http://purl.uniprot.org/citations/15224091 | http://purl.uniprot.org/core/author | "Kloetzel P.M."xsd:string |
| http://purl.uniprot.org/citations/15224091 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15224091 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/15224091 | http://purl.uniprot.org/core/pages | "661-669"xsd:string |
| http://purl.uniprot.org/citations/15224091 | http://purl.uniprot.org/core/title | "Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII."xsd:string |
| http://purl.uniprot.org/citations/15224091 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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