| http://purl.uniprot.org/citations/15226359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15226359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15226359 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively acquire peptides without any detectable incorporation into the transporter associated with Ag presentation (TAP)-associated peptide loading complex even under conditions of extreme peptide starvation. This mode of peptide capture is less susceptible to viral interference than the conventional loading pathway used by HLA-B*4402 that involves assembly of class I molecules within the peptide loading complex. Thus, B*4402 and B*4405 are at opposite extremes of a natural spectrum in HLA class I dependence on the PLC for Ag presentation. These findings unveil a new layer of MHC polymorphism that affects the generic pathway of Ag loading, revealing an unsuspected evolutionary trade-off in selection for optimal HLA class I loading versus effective pathogen evasion."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031680"xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031680"xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Bottomley S.P."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Bottomley S.P."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Chang L."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Chang L."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Beddoe T."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Beddoe T."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Brooks A.G."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Brooks A.G."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Ely L.K."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Ely L.K."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Kjer-Nielsen L."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Kjer-Nielsen L."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Macdonald W.A."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "Macdonald W.A."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/15226359 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |