| http://purl.uniprot.org/citations/15231748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15231748 | http://www.w3.org/2000/01/rdf-schema#comment | "Access to the human genome facilitates extensive functional proteomics studies. Here, we present an integrated approach combining large-scale protein interaction mapping, exploration of the interaction network, and cellular functional assays performed on newly identified proteins involved in a human signaling pathway. As a proof of principle, we studied the Smad signaling system, which is regulated by members of the transforming growth factor beta (TGFbeta) superfamily. We used two-hybrid screening to map Smad signaling protein-protein interactions and to establish a network of 755 interactions, involving 591 proteins, 179 of which were poorly or not annotated. The exploration of such complex interaction databases is improved by the use of PIMRider, a dedicated navigation tool accessible through the Web. The biological meaning of this network is illustrated by the presence of 18 known Smad-associated proteins. Functional assays performed in mammalian cells including siRNA knock-down experiments identified eight novel proteins involved in Smad signaling, thus validating this integrated functional proteomics approach."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.org/dc/terms/identifier | "doi:10.1101/gr.2334104"xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Legrain P."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Wojcik J."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Colland F."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Trouplin V."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Gauthier J.M."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Jacq X."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Hamburger A."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Mougin C."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Groizeleau C."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/author | "Meil A."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/name | "Genome Res"xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/pages | "1324-1332"xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/title | "Functional proteomics mapping of a human signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/15231748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15231748 |
| http://purl.uniprot.org/citations/15231748 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15231748 |
| http://purl.uniprot.org/uniprot/Q15797#attribution-3E93C435BE77360450CBC88A73238870 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15231748 |
| http://purl.uniprot.org/uniprot/Q9HAU4#attribution-3E93C435BE77360450CBC88A73238870 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15231748 |
| http://purl.uniprot.org/uniprot/#_P11047-mappedCitation-15231748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15231748 |
| http://purl.uniprot.org/uniprot/#_P11233-mappedCitation-15231748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15231748 |
| http://purl.uniprot.org/uniprot/#_P13987-mappedCitation-15231748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15231748 |