| http://purl.uniprot.org/citations/15231994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15231994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15231994 | http://www.w3.org/2000/01/rdf-schema#comment | "Biochemical, genetic, and animal studies in recent years have established a critical role for the adipokine Acrp30/adiponectin in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. We describe a widely expressed and highly conserved family of adiponectin paralogs designated as C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. In the present study, we focus on mCTRP2, the mouse paralog most similar to adiponectin. At nanomolar concentrations, bacterially produced mCTRP2 rapidly induced phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation. The discovery of a family of adiponectin paralogs has implications for understanding the control of energy homeostasis and could provide new targets for pharmacologic intervention in metabolic diseases such as diabetes and obesity."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0403760101"xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0403760101"xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Lodish H.F."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Lodish H.F."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Hug C."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Hug C."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Wong G.W."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Wong G.W."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Tsao T.S."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/author | "Tsao T.S."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/pages | "10302-10307"xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/pages | "10302-10307"xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/title | "A family of Acrp30/adiponectin structural and functional paralogs."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/title | "A family of Acrp30/adiponectin structural and functional paralogs."xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15231994 | http://purl.uniprot.org/core/volume | "101"xsd:string |