Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15237447http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To investigate the association between curative effects of interferon-alpha and partial human leucocyte antigen (HLA) II alleles in chronic viral hepatitis B.

Methods

Sixty patients with chronic viral hepatitis B in Shanghai were treated with a standard course of treatment with interferon-alpha for 6 mo. HLA-DRB1, -DQA1, and -DQB1 alleles were detected by polymerase chain reaction-sequence specific primer (PCR-SSP) method.

Results

Frequencies of HLA-DRB1*04 (P<0.025) and HLA-DQA1*0303 (P<0.01) in non-responders were significantly higher than those in partial and complete responders. Frequencies of HLA-DQA1*0505 (P<0.025) and HLA-DQB1*0301 (P<0.005) in partial and complete responders were significantly higher than those in non-responders.

Conclusion

Non-response to interferon-alpha therapy is positively correlated with HLA-DRB1*04 and HLA-DQA1*0303, and negatively correlated with HLA-DQA1*0505 and -DQB1*0301 in patient with chronic viral hepatitis B. HLA II genes of the identification alleles provide a method for evaluating outcome of interferon-alpha treatment."xsd:string
http://purl.uniprot.org/citations/15237447http://purl.org/dc/terms/identifier"doi:10.3748/wjg.v10.i14.2116"xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/author"Ji Y."xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/author"Yu Y.S."xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/author"Xi M."xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/author"Tang Z.H."xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/author"Feng M.L."xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/author"Zang G.Q."xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/pages"2116-2118"xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/title"Curative effects of interferon-alpha and HLA-DRB1 -DQA1 and -DQB1 alleles in chronic viral hepatitis B."xsd:string
http://purl.uniprot.org/citations/15237447http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/15237447http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15237447
http://purl.uniprot.org/citations/15237447http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15237447
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-15237447http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15237447
▶