| http://purl.uniprot.org/citations/15238359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15238359 | http://www.w3.org/2000/01/rdf-schema#comment | "Maternofetal transport of l-carnitine, a molecule that shuttles long-chain fatty acids to the mitochondria for oxidation, is thought to be important in preparing the fetus for its lipid-rich postnatal milk diet. Using brush-border membrane (BBM) vesicles from human term placentas, we showed that l-carnitine uptake was sodium and temperature dependent, showed high affinity for carnitine (apparent K(m) = 11.09 +/- 1.32 microM; V(max) = 41.75 +/-0.94 pmol.mg protein(-1).min(-1)), and was unchanged over the pH range from 5.5 to 8.5. l-Carnitine uptake was inhibited in BBM vesicles by valproate, verapamil, tetraethylammonium, and pyrilamine and by structural analogs of l-carnitine, including d-carnitine, acetyl-d,l-carnitine, and propionyl-, butyryl-, octanoyl-, isovaleryl-, and palmitoyl-l-carnitine. Western blot analysis revealed that OCTN2, a high-affinity, Na(+)-dependent carnitine transporter, was present in placental BBM but not in isolated basal plasma membrane vesicles. The reported properties of OCTN2 resemble those observed for l-carnitine uptake in placental BBM vesicles, suggesting that OCTN2 may mediate most maternofetal carnitine transport in humans."xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00333.2003"xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/author | "Qureshi I.A."xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/author | "Mitchell G.A."xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/author | "Lafond J."xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/author | "Lahjouji K."xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/author | "Leduc L."xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/author | "Elimrani I."xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/pages | "C263-9"xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/title | "L-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2."xsd:string |
| http://purl.uniprot.org/citations/15238359 | http://purl.uniprot.org/core/volume | "287"xsd:string |
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