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http://purl.uniprot.org/citations/15238514http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15238514http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15238514http://www.w3.org/2000/01/rdf-schema#comment"During meiosis DNA double-strand breaks initiate recombination in the distantly related budding and fission yeasts and perhaps in most eukaryotes. Repair of broken meiotic DNA is essential for formation of viable gametes. We report here distinct but overlapping sets of proteins in these yeasts required for formation and repair of double-strand breaks. Meiotic DNA breakage in Schizosaccharomyces pombe did not require Rad50 or Rad32, although the homologs Rad50 and Mre11 are required in Saccharomyces cerevisiae; these proteins are required for meiotic DNA break repair in both yeasts. DNA breakage required the S. pombe midmeiosis transcription factor Mei4, but the structurally unrelated midmeiosis transcription factor Ndt80 is not required for breakage in S. cerevisiae. Rhp51, Swi5, and Rad22 + Rti1 were required for full levels of DNA repair in S. pombe, as are the related S. cerevisiae proteins Rad51, Sae3, and Rad52. Dmc1 was not required for repair in S. pombe, but its homolog Dmc1 is required in the well-studied strain SK1 of S. cerevisiae. Additional proteins required in one yeast have no obvious homologs in the other yeast. The occurrence of conserved and nonconserved proteins indicates potential diversity in the mechanism of meiotic recombination and divergence of the machinery during the evolution of eukaryotes."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.org/dc/terms/identifier"doi:10.1534/genetics.103.023762"xsd:string
http://purl.uniprot.org/citations/15238514http://purl.org/dc/terms/identifier"doi:10.1534/genetics.103.023762"xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/author"Smith G.R."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/author"Smith G.R."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/author"Young J.A."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/author"Young J.A."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/author"Hyppa R.W."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/author"Hyppa R.W."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/name"Genetics"xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/name"Genetics"xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/pages"593-605"xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/pages"593-605"xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/title"Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/title"Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts."xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/volume"167"xsd:string
http://purl.uniprot.org/citations/15238514http://purl.uniprot.org/core/volume"167"xsd:string
http://purl.uniprot.org/citations/15238514http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15238514
http://purl.uniprot.org/citations/15238514http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15238514
http://purl.uniprot.org/citations/15238514http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15238514
http://purl.uniprot.org/citations/15238514http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15238514