| http://purl.uniprot.org/citations/15238520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15238520 | http://www.w3.org/2000/01/rdf-schema#comment | "Programmed cell death (PCD) is regulated by multiple evolutionarily conserved mechanisms to ensure the survival of the cell. Here we describe pvl-5, a gene that likely regulates PCD in Caenorhabditis elegans. In wild-type hermaphrodites at the L2 stage there are 11 Pn.p hypodermal cells in the ventral midline arrayed along the anterior-posterior axis and 6 of these cells become the vulval precursor cells. In pvl-5(ga87) animals there are fewer Pn.p cells (average of 7.0) present at this time. Lineage analysis reveals that the missing Pn.p cells die around the time of the L1 molt in a manner that often resembles the programmed cell deaths that occur normally in C. elegans development. This Pn.p cell death is suppressed by mutations in the caspase gene ced-3 and in the bcl-2 homolog ced-9, suggesting that the Pn.p cells are dying by PCD in pvl-5 mutants. Surprisingly, the Pn.p cell death is not suppressed by loss of ced-4 function. ced-4 (Apaf-1) is required for all previously known apoptotic cell deaths in C. elegans. This suggests that loss of pvl-5 function leads to the activation of a ced-3-dependent, ced-4-independent form of PCD and that pvl-5 may normally function to protect cells from inappropriate activation of the apoptotic pathway."xsd:string |
| http://purl.uniprot.org/citations/15238520 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.103.020503"xsd:string |
| http://purl.uniprot.org/citations/15238520 | http://purl.uniprot.org/core/author | "Eisenmann D.M."xsd:string |
| http://purl.uniprot.org/citations/15238520 | http://purl.uniprot.org/core/author | "Joshi P."xsd:string |
| http://purl.uniprot.org/citations/15238520 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15238520 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15238520 | http://purl.uniprot.org/core/pages | "673-685"xsd:string |
| http://purl.uniprot.org/citations/15238520 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans pvl-5 gene protects hypodermal cells from ced-3-dependent, ced-4-independent cell death."xsd:string |
| http://purl.uniprot.org/citations/15238520 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/15238520 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15238520 |
| http://purl.uniprot.org/citations/15238520 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15238520 |
| http://purl.uniprot.org/uniprot/#_D3YT61-mappedCitation-15238520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15238520 |
| http://purl.uniprot.org/uniprot/#_P30429-mappedCitation-15238520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15238520 |
| http://purl.uniprot.org/uniprot/#_P42573-mappedCitation-15238520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15238520 |
| http://purl.uniprot.org/uniprot/P42573 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15238520 |
| http://purl.uniprot.org/uniprot/P30429 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15238520 |
| http://purl.uniprot.org/uniprot/D3YT61 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15238520 |