| http://purl.uniprot.org/citations/15239346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15239346 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment. These proteins have been implicated in tumor invasion and metastasis. Therefore, we aimed at investigating the prognostic significance of MMP-2, CD, and TN-C expressions in primary colorectal cancer. Overall, 112 colorectal adenocarcinomas were included in the present study. MMP-2, CD, and TN-C expressions were evaluated by immunohistochemistry and correlated with clinicopathologic prognostic parameters and survival. Diffuse stromal TN-C immunostaining was found to be significantly correlated with advanced stage and shorter survival time (p = 0.002 and 0.02, respectively). MMP-2 expression was found to correlate with lymph vessel invasion (p = 0.006) and stage (p = 0.03). CD expression was related to depth of invasion (p = 0.005). No significant relationship was found between survival and MMP-2 and CD expression (p > 0.05). In multivariate analysis, stage and vascular invasion were independent prognostic factors, whereas TN-C did not retain a clear independent relationship to survival (p > 0.05). Our findings suggest that TN-C expression may be a potential prognostic marker in colorectal carcinoma. However, MMP-2 and CD do not appear to be significant indicators of survival."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.prp.2004.02.012"xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/author | "Bishop P."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/author | "Sagol O."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/author | "Fuzun M."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/author | "Kupelioglu A."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/author | "Sokmen S."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/author | "Ozer E."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/author | "Sis B."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/author | "Terzi C."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/name | "Pathol Res Pract"xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/pages | "379-387"xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/title | "Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma."xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://purl.uniprot.org/core/volume | "200"xsd:string |
| http://purl.uniprot.org/citations/15239346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15239346 |
| http://purl.uniprot.org/citations/15239346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15239346 |
| http://purl.uniprot.org/uniprot/#_D3YHM4-mappedCitation-15239346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15239346 |
| http://purl.uniprot.org/uniprot/#_Q15566-mappedCitation-15239346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15239346 |
| http://purl.uniprot.org/uniprot/#_B4E1W8-mappedCitation-15239346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15239346 |
| http://purl.uniprot.org/uniprot/#_A7MBN2-mappedCitation-15239346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15239346 |
| http://purl.uniprot.org/uniprot/#_A9YUB8-mappedCitation-15239346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15239346 |
| http://purl.uniprot.org/uniprot/#_J3QSU6-mappedCitation-15239346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15239346 |
| http://purl.uniprot.org/uniprot/#_Q4LE33-mappedCitation-15239346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15239346 |