| http://purl.uniprot.org/citations/15240665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15240665 | http://www.w3.org/2000/01/rdf-schema#comment | "Although HLA-DQ8 has been implicated as a key determinant of genetic susceptibility to human type 1 diabetes, spontaneous diabetes has been observed in HLA-DQ8 transgenic mice that lack expression of murine MHC class II molecules (mII(-/-)) only when the potent costimulatory molecule, B7.1, is transgenically expressed on pancreatic beta cells. To study the contribution of HLA-DQ8 to the development of diabetes in this model, we crossed RIP-B7.1mII(-/-) mice with a set of transgenic mouse lines that differed in their HLA-DQ8 expression patterns on APC subpopulations, in particular dendritic cells and cortical thymic epithelial cells. Surprisingly, we found that even in the absence of HLA-DQ8 and CD4 T cells, a substantial fraction of the RIP-B7.1mII(-/-) mice developed diabetes. This disease process was remarkable for not only showing insulitis, but also inflammatory destruction of the exocrine pancreas with diffusely up-regulated expression of MHC class I and ICAM-1 molecules. Expression of HLA-DQ8 markedly increased the kinetics and frequency of diabetes, with the most severe disease in the lines with the highest levels of HLA-DQ8 on cortical thymic epithelial cells and the largest numbers of CD4 T cells. However, the adoptive transfer of diabetes was not HLA-DQ8-dependent and disease could be rapidly induced with purified CD8 T cells alone. Expression of B7.1 in the target tissue can thus dramatically alter the cellular and molecular requirements for the development of autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.2.787"xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/author | "Klein L."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/author | "Taylor J.A."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/author | "Lennon-Dumenil A.M."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/author | "Lipes M.A."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/author | "Wucherpfennig K.W."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/author | "Neely D."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/author | "McInerney M.F."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/author | "Havari E."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/pages | "787-796"xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/title | "Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/15240665 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15240665 |
| http://purl.uniprot.org/citations/15240665 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15240665 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-15240665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15240665 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-15240665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15240665 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-15240665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15240665 |
| http://purl.uniprot.org/uniprot/#_P06342-mappedCitation-15240665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15240665 |
| http://purl.uniprot.org/uniprot/#_P06343-mappedCitation-15240665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15240665 |
| http://purl.uniprot.org/uniprot/#_P06345-mappedCitation-15240665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15240665 |
| http://purl.uniprot.org/uniprot/#_P06346-mappedCitation-15240665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15240665 |