| http://purl.uniprot.org/citations/15242649 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15242649 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15242649 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for the neuronal toxicity associated with Huntington's disease (HD). Although wild-type huntingtin possesses antiapoptotic properties, the relationship between the neuroprotective functions of huntingtin and pathogenesis of HD remains unclear. Here, we show that huntingtin specifically enhances vesicular transport of brain-derived neurotrophic factor (BDNF) along microtubules. Huntingtin-mediated transport involves huntingtin-associated protein-1 (HAP1) and the p150(Glued) subunit of dynactin, an essential component of molecular motors. BDNF transport is attenuated both in the disease context and by reducing the levels of wild-type huntingtin. The alteration of the huntingtin/HAP1/p150(Glued) complex correlates with reduced association of motor proteins with microtubules. Finally, we find that the polyQ-huntingtin-induced transport deficit results in the loss of neurotrophic support and neuronal toxicity. Our findings indicate that a key role of huntingtin is to promote BDNF transport and suggest that loss of this function might contribute to pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.06.018"xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.06.018"xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Saudou F."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Saudou F."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Humbert S."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Humbert S."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "MacDonald M.E."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "MacDonald M.E."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Dompierre J.P."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Dompierre J.P."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Lessmann V."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Lessmann V."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "De Mey J."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "De Mey J."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Borrell-Pages M."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Borrell-Pages M."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Charrin B.C."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Charrin B.C."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Cordelieres F.P."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Cordelieres F.P."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Gauthier L.R."xsd:string |
| http://purl.uniprot.org/citations/15242649 | http://purl.uniprot.org/core/author | "Gauthier L.R."xsd:string |