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Background

Human leukocyte antigens have become key components to investigate the genetic relationships between populations.

Objective

The aim of this study was to determine the genetic diversity of HLA class I and II alleles among the Baloch ethnic group of southeastern in comparison with the Parsi ethnic group, thereby establishing a database for further investigations on the ancestry and genetic factors contributing to complex diseases in this region.

Materials and methods

Thirty unrelated Balochi individuals from southeast Iran and 108 Parsi unrelated individuals were serologically typed using standard microcytotoxicity assays with commercial and local trays.

Results

The most frequent class I alleles of the Baloch ethnic group were HLA-A01 (53.3%), -A02 (30%), -A09 (23.3%), -A11 (20%), -A23 (23.3%), -B05 (53.3%), and -B08 (26.7%). The class II alleles more frequently observed were HLA-DR1 (26.7%), -DR2 (43.3%), -DR3 (20%), -DR4 (33.3%), -DR7 (26.7%), -DR11 (33.7%), -DRw52 (83.3%), -DRw53 (36.7%), -DQ1 (46.7%), -DQ2 (20%), and -DQ3 (40%). In contrast with the Parsi ethnic group, the frequencies for the following alleles were significantly higher in Baloch than Parsi. HLA-A01, -A23, -A25, -B05, -B08, -B16, -B17, -B60, -DR14, -DQ4, and -DQ7. In contrast, the frequencies of HLA-Cw4 and -DQ3 alleles in the Parsi were significantly higher than the Baloch ethnic group.

Conclusions

This first study of HLA in widely dispersed areas of Iran represents an important resource for investigators in the fields of transplantation immunology and population genetics."xsd:string
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http://purl.uniprot.org/citations/15251317http://purl.uniprot.org/core/title"Major histocompatibility complex class I and II antigens frequencies in Baloch ethnic group living in the southeast region of Iran."xsd:string
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