| http://purl.uniprot.org/citations/15251454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15251454 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumour necrosis factor receptor 1 (TNFR1) plays a critical role in host defence and inflammation. We have identified a membrane proximal region (aa 218-324) of TNFR1 that restricts surface expression. This was prompted by comparing the dominant-negative properties of a C-terminal truncation of TNFR1 with a point mutant that prevents signalling. C-terminal truncation (aa 218-426) generates a better dominant-negative TNFR1 mutant than inactivation of the death domain by point mutation. The increased dominant-negative activity correlates with increased cell surface expression. The membrane proximal region is the most important region of the receptor for restricting expression."xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2004.06.035"xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/author | "Rowe M."xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/author | "Brennan P."xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/author | "Fielding C.A."xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/author | "Siebert S."xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/pages | "138-142"xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/title | "Analysis of human tumour necrosis factor receptor 1 dominant-negative mutants reveals a major region controlling cell surface expression."xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://purl.uniprot.org/core/volume | "570"xsd:string |
| http://purl.uniprot.org/citations/15251454 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15251454 |
| http://purl.uniprot.org/citations/15251454 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15251454 |
| http://purl.uniprot.org/uniprot/#_J9PH39-mappedCitation-15251454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15251454 |
| http://purl.uniprot.org/uniprot/#_P19438-mappedCitation-15251454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15251454 |
| http://purl.uniprot.org/uniprot/#_Q6Y4Q7-mappedCitation-15251454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15251454 |
| http://purl.uniprot.org/uniprot/Q6Y4Q7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15251454 |
| http://purl.uniprot.org/uniprot/P19438 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15251454 |
| http://purl.uniprot.org/uniprot/J9PH39 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15251454 |