| http://purl.uniprot.org/citations/15253154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15253154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15253154 | http://www.w3.org/2000/01/rdf-schema#comment | "PD-L2, a newly identified member of B7 family, plays a role in down-regulating T cell responses. The common PD-L2 mRNA (type I) is the splicing product containing all 6 exons. We report here the identification of two human PD-L2 splice variants in activated leukocytes. One splice variant (type II) is generated through splicing out exon 3 encoding Ig constant-like domain; it retains all other regions without a frame shift. The other variant (type III) is created by splicing out exon 3 to an alternative acceptor site 5 bp downstream of the canonical acceptor site, leading to a frame shift. Consequently, the translated protein should be a soluble form. Furthermore, type I isoform is expressed on the plasma surface whereas type II isoform showed a pattern of intracellular membrane distribution in the transiently transfected K562 cells. In addition, the expression patterns of PD-L2 splice variants are variable in different individuals and distinct cellular status. These results suggest that PD-L2 expression may be controlled by posttranscriptional regulation through alternative splicing, and modulation of PD-L2 isoform expression may influence the outcome of immune response."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.org/dc/terms/identifier | "doi:10.1093/abbs/36.4.284"xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.org/dc/terms/identifier | "doi:10.1093/abbs/36.4.284"xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/author | "He X.-H."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/author | "He X.-H."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/author | "Xu L.-H."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/author | "Xu L.-H."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/author | "Zeng Y.-Y."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/author | "Zeng Y.-Y."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/name | "Acta Biochim. Biophys. Sin."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/name | "Acta Biochim. Biophys. Sin."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/pages | "284-289"xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/pages | "284-289"xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/title | "Cloning and identification of two novel splice variants of human PD-L2."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/title | "Cloning and identification of two novel splice variants of human PD-L2."xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/15253154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15253154 |
| http://purl.uniprot.org/citations/15253154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15253154 |