| http://purl.uniprot.org/citations/15254224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15254224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15254224 | http://www.w3.org/2000/01/rdf-schema#comment | "Because a temporal arrest in the G(1) phase of the cell cycle is thought to be a prerequisite for cell differentiation, we investigated cell cycle factors that critically influence the differentiation of mouse osteoblastic MC3T3-E1 cells induced by bone morphogenetic protein 2 (BMP-2), a potent inducer of osteoblast differentiation. Of the G(1) cell cycle factors examined, the expression of cyclin-dependent kinase 6 (Cdk6) was found to be strongly down-regulated by BMP-2/Smads signaling, mainly via transcriptional repression. The enforced expression of Cdk6 blocked BMP-2-induced osteoblast differentiation to various degrees, depending on the level of its overexpression. However, neither BMP-2 treatment nor Cdk6 overexpression significantly affected cell proliferation, suggesting that the inhibitory effect of Cdk6 on cell differentiation was exerted by a mechanism that is largely independent of its cell cycle regulation. These results indicate that Cdk6 is a critical regulator of BMP-2-induced osteoblast differentiation and that its Smads-mediated down-regulation is essential for efficient osteoblast differentiation."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.15.6560-6568.2004"xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.15.6560-6568.2004"xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Kawaguchi H."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Kawaguchi H."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Nakamura K."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Nakamura K."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Ogasawara T."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Ogasawara T."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Okayama H."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Okayama H."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Hoshi K."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Hoshi K."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Jinno S."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Jinno S."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Itaka K."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Itaka K."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Takato T."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/author | "Takato T."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/15254224 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |