| http://purl.uniprot.org/citations/15257289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15257289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15257289 | http://www.w3.org/2000/01/rdf-schema#comment | "H2A.Bbd is an unusual histone variant whose sequence is only 48% conserved compared to major H2A. The major sequence differences are in the docking domain that tethers the H2A-H2B dimer to the (H3-H4)(2) tetramer; in addition, the C-terminal tail is absent in H2A.Bbd. We assembled nucleosomes in which H2A is replaced by H2A.Bbd (Bbd-NCP), and found that Bbd-NCP had a more relaxed structure in which only 118+/-2 bp of DNA is protected against digestion with micrococcal nuclease. The absence of fluorescence resonance energy transfer between the ends of the DNA in Bbd-NCP indicates that the distance between the DNA ends is increased significantly. The Bbd docking domain is largely responsible for this behavior, as shown by domain-swap experiments. Bbd-containing nucleosomal arrays repress transcription from a natural promoter, and this repression can be alleviated by transcriptional activators Tax and CREB. The structural properties of Bbd-NCP described here have important implications for the in vivo function of this histone variant and are consistent with its proposed role in transcriptionally active chromatin."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600316"xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600316"xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Park Y.-J."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Park Y.-J."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Bao Y."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Bao Y."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Dyer P.N."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Dyer P.N."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Luger K."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Luger K."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Rangasamy D."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Rangasamy D."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Laybourn P.J."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Laybourn P.J."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Konesky K."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Konesky K."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Rosu S."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Rosu S."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Tremethick D.J."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/author | "Tremethick D.J."xsd:string |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15257289 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |